He added: “As we learn more and more about how cells function, we’re learning more about how we can control that functionality…which is particularly important in dealing with cells that go rogue in dis,eases ranging from cancer to Alzheimer’s.” Paul Wender, professor of chemistry and, by courtesy, of chemical and systems biology at Stanford commented: “…my colleagues…were able to do something many people had considered impossible.” Extra oxygen atoms were added to phorbol’s B ring, a part of the molecule selected for modification. To develop the drug, researchers used a Chinese herbal medicine called Croton tiglium (purging croton), which has an active pharmaceutical ingredient (API) called phorbol. The team used lab equipment at the Stanford Neuroscience Microscopy Service, the Stanford Cancer Institute Proteomics/Mass Spectrometry Shared Resource and the Stanford Sherlock cluster for computer modelling.
The team at Stanford University applied this knowledge and synthesised it for real-world use. QBiotics, a biotech firm in Australia, initially identified tigilanol tiglate as potentially useful for drug development.
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